CoreLab’s partnership campaign was launched in 2014 to promote awareness of PPC’s incubation platform and funding models that are designed to foster collaboration work that address the following therapeutic categories:

1. Metabolic Syndrome
2. Cancer
3. Tropical Diseases

Since then, PPC has established R&D partnerships with various universities like UP, Ateneo, and Technological Institute of the Philippines through research grants totaling around 120M PHP from USAID, PCARI-CHED, and DOST-PCHRD. Building on the commercialization success of Sambong, PPC and its collaborators have developed platforms for quality control of herbal raw materials, diagnostic tools for diseases, and data analytics for complex mixtures.

Through CoreLab, PPC advocates that, together, we can put more science into the development of natural product-based medicines that are safe, efficacious, and accessible to all Filipinos from all walks of life.

R & D Head

Paul S. Tabudlong

PPC R&D Collaboration Network

Analytical Services

Natural Products and Pharmaceutical Analysis

Are you interested in determining the composition of your herbal raw materials? We have lab-scale capabilities in raw material drying, extraction, and fractionation with material characterization using LC-MS/MS and UV. Please email us at corelab@pascualpharma.com for inquiries and include information on the type of material you are working with and the types of compounds you are looking for.

Method Development and Validation/Verification

We provide analytical method development and validation solutions via LC-MS/UV to suit your intended purpose. We can also verify existing USP methods based on LC-UV for your specific material or formulation. Please email us at corelab@pascualpharma.com for your specific regulatory needs, R&D, and GMP applications.

Our Tools and Methods

We work with clients to ensure test methods are appropriate for their intended use by identifying and using an appropriate scientifically valid method for each established specification.

Major Analytical Equipment

Ultraperformance liquid chromatograph (UPLC) with two (2) available detectors

• Photodiode array detector (PDA)

• Electrospray ionization − quadrupole time-of-flight − tandem mass spectrometer (ESI-QTOF-MS/MS)

UV-Vis spectrophotometer (microplate reader format)

Quality & Accreditations

We are committed to performing quality analyses. Our quality system and procedures ensure the integrity, accuracy, precision, reliability, and timeliness of your data. By choosing Pascual Pharma as your testing partner, you can feel confident that the methods used to test your samples and the reported results are transparent, credible, and scientifically valid.

Published Scientific Articles and Conference Proceedings:

1. Azur, R.G.; Padolina, I.D.; Bagamasbad, P.D. (2020). Luminescence-based drug screen for novel androgen receptor antagonists for prostate cancer therapy [abstract]. Journal of the Endocrine Society, 4, Supplement_1, April-May 2020: SUN-139. 10.1210/jendso/bvaa046.1189

1. Sibug-Torres, S.; Padolina, I.D.; Enriquez, E.P. (2019). Radial multi-stationary phase thin-layer chromatography for the field-ready fingerprinting of herbal materials. Analytical Methods, 11: 5511-5520. 10.1039/C9AY01714C

1. Sibug-Torres, S.; Padolina, I.D.; Cruz, P.; Garcia, F.; Garrovillas, M.; Yabillo, M.; Enriquez, E.P. (2019). Smartphone-based image analysis and chemometric pattern recognition of the thin-layer chromatographic fingerprints of herbal materials. Analytical Methods, 11: 721-732. 10.1039/C8AY02698J

1. Nacario, R.C.; Completo, G.J.; Reyes, J.M.; Heralde, F.M.; Barzaga, M.A.; Tan-Liu, N.; Ladrera, G.; Danguilan, J.; Moreno, P.G.; Rabajante, J.F.; Padolina, I.D.; Lebrilla, C.B. (2018). Exploring protein interactions in non-small cell lung cancer-associated glycoproteins through mass spectrometry and StringDB. Chemical Sciences Journal, 9: 28. doi:4172/2150-3494-C5-030

Awards and Recognitions:

1. NSTW Awards: 2020 Outstanding Research and Development Award for Applied Research (Julian A. Banzon Medal)
   Dr. Erwin P. Enriquez, with co-authors: Sarah May Sibug-Torres, and Dr. Isagani D. Padolina, for the research on “Field-ready tools for fingerprinting of herbal materials for the medicinal plant industry”.

Patents and Copyrights:

1. University of the Philippines Los Baños, Pascual Pharma Corp., Lung Center of the Philippines, and University of California Davis. (May 1, 2019). GlycoLINC Network Toolbox. Copyright Registration No. O2019-3951.

Research Conference Presentations:

1. Padolina, I.D.; Abogado, R.P. (2020). The choices we have to make for industry-academe partnerships in Philippine-based healthcare research and commercialization. 40th Annual Philippine-American Academy of Science and Engineering Meeting & Symposium (Online; August 6-10, 2020).

1. Azur, R.G.; Abogado, R.P.; Padolina, I.D.; Bagamasbad, P.D. (2020). Targeted screening assay for identifying novel AR antagonists for prostate cancer therapy. 40th Annual Philippine-American Academy of Science and Engineering Meeting & Symposium (Online; August 6-10, 2020). ‒ First Prize, Rapid Fire Competition – Disease, Medicine and Pharmaceutical Science Cluster

1. Serrano, L.N.; Wong, M.Y.; Lebrilla, C.B.; Reyes, J.M.; Rabajante, J.F.; Heralde, F.M.; Moreno, P.G.; Cabanatan, M.M.; Completo, G.J.; Padolina, I.D.; Nacario, R.C. (2020). Tandem mass spectrometry-based glycomic technologies enable glycome profiling of serum samples from Filipino non-small cell lung cancer (NSCLC) cases. National Academy of Science and Technology Philippines 42^nd Annual Scientific Meeting (Online; July 7-10, 2020). ‒ Best Scientific Poster (Biological Sciences) Award

1. Serrano, L.N.; Wong, M.Y.; Lebrilla, C.B.; Reyes, J.M.; Rabajante, J.F.; Heralde, F.M.; Moreno, P.G.; Cabanatan, M.M.; Padolina, I.D.; Completo, G.J.; Nacario, R.C. (2020). Deciphering the glycopatterns of sera samples from Filipino non-small cell lung cancer (NSCLC) patients using high-throughput mass spectrometry-based techniques. National Research Council of the Philippines Annual Research Conference (Online; May 27, 2020). ‒ 2^nd Place, Best Poster Award

1. Serrano, L.; Wong, M.; Lebrilla, C.; Reyes, J.; Padolina, I.; Heralde, F.; Completo, G.; Nacario, R.C. (2019). Monosialylated glycans found in higher levels in cancer FFPE specimen. 18^th Asian Chemistry Congress (Taipei, Taiwan; December 8-12, 2019).

1. Serrano, L.; Nacario, R; Completo, G.; Heralde, F.; Padolina, I.; Reyes, J.; Alvarez, M.; Wong, M.; Lebrilla, C. (2019). 3D-cultured NSCLC cells express higher levels of fucosylated and sialylated N-glycans. International Union of Biochemistry and Molecular Biology Education Conference 2019 and 46^th Philippine Society of Biochemistry and Molecular Biology Annual Convention (Manila, Philippines; November 13-15, 2019). ‒ Best Poster Paper Award

1. Macapagal, D.D.; Tomacas, S.T.; Cabanatan, M.M.; Moreno, P.G.; Tan-Liu, N.; Barzaga, M.A.; Heralde, F.M.; Rabajante, J.F.; Completo, G.J.; Padolina, I.D.; Lebrilla, C.B.; Nacario, R.C. (2019). Effects of Mangifera indica on the in vitro cell migration of lung adenocarcinoma cell line (A549) through scratch assay. International Union of Biochemistry and Molecular Biology Education Conference 2019 and 46^th Philippine Society of Biochemistry and Molecular Biology Annual Convention (Manila, Philippines; November 13-15, 2019).

1. Abogado, R.P.; Delica, K.M.; Deniega, F.G.; Basingan, M.L.; Alvarez, M.S.; Nacario, R.C.; Completo, G.J.; Padolina, I.D. (2019). Potassium-sparing diuretic potential of selected Philippine plants by Na⁺/K⁺-ATPase inhibition. 48th Annual Convention Kapisanang Kimika ng Pilipinas – Southern Tagalog Chapter (Bay, Laguna, Philippines; September 5-6, 2019).

1. Serrano, L.; Reyes, J.; Heralde, F.; Padolina, I.; Wong, M.; Alvarez, M.;
   Completo, G.; Lebrilla, C.; Nacario, R. (2019). Mass spectrometry-based OMICS analysis highlight differences in protein N-glycosylation of 2D- and 3D-cultured lung cancer cells. 48th Annual Convention Kapisanang Kimika ng Pilipinas – Southern Tagalog Chapter (Bay, Laguna, Philippines; September 5-6, 2019). ‒ Best Oral Paper Award

1. Abogado, R.; Deniega, F.; Basingan, M.; Delica, K.; Alvarez, M.; Completo, G.; Nacario, R.; Padolina, I. (2019). Development and validation of a liquid chromatographic method for the simultaneous determination of major flavonoids in Blumea balsamifera. 34th Philippine Chemistry Congress (Cebu City, Cebu, Philippines; May 28-30, 2019).

1. Alvarez, M.; Serrano, L; Delica, K.; Moreno, P.; Abogado, R.; Basingan, M.; Deniega, F.; Grijaldo, S.; Macapagal, D.; Apelado, M.; Cabanatan, M.; Reyes, J.; Gapac, G.; Narciso, M.; Yanos, L.; Gestiada, E.; Malayba, A.; Alegre, A.; Rabajante, J.; Padolina, I.; Heralde, F.; Completo, G.; Lebrilla, C.; Nacario, R. (2019). Possible mechanism of cytotoxic activity of Annona muricata extracts against lung cancer cells. 34th Philippine Chemistry Congress (Cebu City, Cebu, Philippines; May 28-30, 2019).

1. Basingan, M.; Delica, K.; Alvarez, M.; Moreno, P.; Deniega, F.; Abogado, R.; Grijaldo, S.; Macapagal, D.; Apelado, M.; Cabanatan, M.; Reyes, J.; Gapac, G.; Narciso, M.; Yanos, L.; Gestiada, E.; Malayba, A.; Alegre, A.; Rabajante, J.; Padolina, I.; Heralde, F.; Completo, G.; Lebrilla, C.; Nacario, R. (2019). Anticancer screening and metabolite profiling of plant extracts from Mt. Makiling. 34th Philippine Chemistry Congress (Cebu City, Cebu, Philippines; May 28-30, 2019).

1. Delica, K.; Alvarez, M.; Moreno, P.; Abogado, R.; Basingan, M.; Deniega, F.; Grijaldo, S.; Macapagal, D.; Apelado, M.; Cabanatan, M.; Reyes, J.; Gapac, G.; Narciso, M.; Yanos, L.; Gestiada, E.; Malayba, A.; Alegre, A.; Rabajante, J.; Padolina, I.; Heralde, F.; Completo, G.; Lebrilla, C.; Nacario, R. (2019). Purification and characterization of lung cancer cytotoxic compounds from Annona muricata, Mangifera indica, and Lansium parasiticum 34th Philippine Chemistry Congress (Cebu City, Cebu, Philippines; May 28-30, 2019).

1. Deniega, F.; Quizon, C.; Alvarez, M.; Moreno, P.; Delica, K.; Abogado, R.; Basingan, M.; Grijaldo, S.; Macapagal, D.; Apelado, M.; Cabanatan, M.; Reyes, J.; Gapac, G.; Narciso, M.; Yanos, L.; Gestiada, E.; Malayba, A.; Alegre, A.; Rabajante, J.; Padolina, I.; Heralde, F.; Completo, G.; Lebrilla, C.; Nacario, R. (2019). Comparison of drying and extraction methods in terms of yield, metabolite profile and anticancer activity of Mangifera indica 34th Philippine Chemistry Congress (Cebu City, Cebu, Philippines; May 28-30, 2019).

1. Moreno, P.G.; Cabanatan, M.M.; Macapagal. D.D.; Apelado, M.B.; Tan-Liu, N.; Barzaga, M.A.; Heralde, F.M.; Rabajante, J.F.; Completo, G.C.; Padolina, I.D.; Lebrilla, C.B.; Nacario, R.C. (2019). Preliminary immortalization of lung adenocarcinoma primary cells from a Filipino patient using CDK4 and hTERT genes. 2019 Annual Philippine-American Academy of Science and Engineering Meeting & Symposium (Manila, Philippines; May 23-24, 2019).

1. Macapagal, D.D.; Moreno, P.G.; Cabanatan, M.M.; Apelado, M.B.; Rabajante J.F.; Completo, G.C.; Padolina, I.D.; Lebrilla, C.B.; Nacario, R.C.; Tan-Liu, N.; Barzaga, M.A.; Heralde, F.M. (2019). Preliminary study on spheroid formation and paraffin embedding of Asian-derived CDK4-transformed lung adenocarcinoma cells. 2019 Annual Philippine-American Academy of Science and Engineering Meeting & Symposium (Manila, Philippines; May 23-24, 2019).

1. Cabanatan, M.M.; Apelado, M.B.; Moreno, P.G.; Macapagal, D.D.; Rabajante, J.F.; Completo, G.C.; Padolina, I.D.; Lebrilla, C.B.; Nacario, R.C.; Tan-Liu, N.; Barzaga, M.A.; Heralde, F.M. (2019). Issues and challenges in patient recruitment of Filipino lung cancer adenocarcinoma cases for a glycoproteomics clinical trial. 2019 Annual Philippine-American Academy of Science and Engineering Meeting & Symposium (Manila, Philippines; May 23-24, 2019).

1. Alvarez, M.; Moreno, P.; Delica, K.; Abogado, R.; Deniega, F.; Basingan, M.; Grijaldo, S.; Macapagal, D.; Apelado, M.; Cabanatan, M.; Reyes, J.; Gapac, G.; Narciso, M.; Gestiada, E.; Malayba, A.; Alegre, A.; Rabajante, J.; Padolina, I.; Heralde, F.; Completo, G.; Nacario, R.; Lebrilla, C. (2019). Generation of natural products library from terrestrial plants of Mt. Makiling, Laguna for anticancer screening. 2019 Annual Philippine-American Academy of Science and Engineering Meeting & Symposium (Manila, Philippines; May 23-24, 2019).

1. Rabajante, J.F.; Narciso, M.P.; Gapac, G.F.; Reyes, J.M.; Lao, A.R.; del Rosario, R.; Padolina, I.D.; Completo, G.J.; Nacario, R.C.; Lebrilla, C.B. (2019). Glycosylation-associated gene co-expression network approach for lung adenocarcinoma biomarker discovery. International Workshop on Mathematical Biology 2019 (Bohol, Philippines; January 26-30, 2019).

1. Alvarez, M.; Delica, K.; Deniega, F.; Basingan, M.; Grijaldo, S.; Moreno, P.; Heralde, F.; Abogado, R.; Padolina, I.; Completo, G.; Nacario, R. (2019). Mount Makiling Natural Products Library (MMNPL): Generation of natural products library, anticancer screening, and characterization by tandem mass spectrometry and in silico analyses. 10th International Symposium of Innovative Bio-Production – Kobe (Kobe, Japan; January 24-25, 2019).

1. Alvarez, M.; Delica, K.; Basingan, M.; Deniega, F.; Cadiente, L.; Abogado, R.; Padolina, I., Completo, G.; Nacario, R. (2018). Metabolite profiling and predicted anticancer activities of fruit trees from Mt. Makiling, Laguna, Philippines. Bromo Conference 2018: Symposium on Natural Products & Biodiversity (Surabaya, East Java, Indonesia; July 11-12, 2018)

1. Sibug, S.; Salatan, F.; Tabudlong, P.; Padolina, I.; Cruz, P.; Enriquez, E. (2017). Field-ready quality assurance test kits and mobile app for the contract farming medicinal plant industry. 254th American Chemical Society National Meeting (Washington DC, USA; August 20, 2017).

1. Sibug, S.; Salatan, F.; Enriquez, E.; Padolina, I.; Garcia, F.; Garrovillas, M. (2017). Image analysis and chemometric one-class classification of Blumea balsamifera thin-layer chromatography towards rapid quality assessment. 254th American Chemical Society National Meeting (Washington DC, USA; August 20, 2017).

1. Sibug, S.R.; Salatan, F.; Padolina, I.; Enriquez, E.P.; Garcia, F.; Garrovillas, M.M. (2017). Chemometric one-class classifiers of Vitex negundo thin-layer chromatography fingerprints towards rapid quality assessment. 32nd Philippine Chemistry Congress (Puerto Princesa City, Palawan, Philippines; May 31 – June 2, 2017).

1. Sibug, S.; Salatan, F.; Timbol, J.; Garcia, F.; Garrovillas, M.; Cruz, P.; Tabudlong, P.; Padolina, I.D.; Enriquez, E.P. (2016). Field-ready quality assurance test kits and mobile app for the contract farming medicinal plant industry. 1^st Philippine Herbal Medicines Summit (Manila, Philippines; October 25-27, 2016).

1. Sibug, S.; Salatan, F.; Timbol, J.; Garcia, F.; Garrovillas, M.; Cruz, P.; Tabudlong, P.; Padolina, I.D.; Enriquez, E.P. (2016). Field-ready quality assurance test kits and mobile app for the contract farming medicinal plant industry. 2016 NAST-AASSA Annual Meeting (Manila, Philippines; September 28-29, 2016).

1. Sibug, S.; Salatan, F.; Timbol, J.; Garcia, F.; Garrovillas, M.; Cruz, P.; Tabudlong, P.; Padolina, I.D.; Enriquez, E.P. (2016). Field-ready quality assurance test tits and mobile app for water activity and plant extract profile. Synergy 2016 (Taguig City, Philippines; September 21-22, 2016).

1. Sibug, S.R.; Salatan, F.; Padolina, I.D.; Cruz, P.; Kierulf, A.; Enriquez, E.P. (2016). Image analysis of abbreviated thin-layer chromatography profiles of Blumea balsamifera towards rapid quality assessment. 31st Philippine Chemistry Congress (Iloilo City, Iloilo, Philippines; April 13-15, 2016).

1. GlycoLINC Network Toolbox (http://glinct.weebly.com)

1. BluQ: Plant + Water (http://www.bluq.tech)

We can partner with your institutional internship programs.  Come join us to supplement your formal education with exposure to different aspects of pharmaceutical R&D and Quality Assurance! We screen year-round applications for student and faculty internships. Send your resume at corelab@pascualpharma.com.

Address: UPLB Science & Technology Park, Brgy. Tuntungin-Putho, Los Baños, Laguna 4031 Philippines

Tel: +63 49 572 0073

Email: corelab@pascualpharma.com